We describe a new species, Epipedobates darwinwallacei sp. nov., from the area of Mindo, on northwestern Ecuador. It inhabits low montane forests in an elevational range of about 1250-1390 m. It differs from all congeneric species by its strong aposematic coloration and tarsal keels. Among species of Epipedobates, the new species has been confused with E. boulengeri and E. espinosai, but it differs from them by its dorsal coloration with bright orange to yellow spots.
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