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ACI Avances en Ciencias e Ingenierías

Bionucleares 2020

Vol. 12 No. 3 (2020): Aplicaciones Nucleares (2021)

Evaluación in vivo del efecto genotóxico y citotóxico de los extractos acuosos de dos variedades mutantes de Hibiscus sabdariffa L.

DOI
https://doi.org/10.18272/aci.v12i3.1933
Submitted
August 12, 2020
Published
2021-05-05

Abstract

The Hibiscus sabdariffa (Jamaica flower, grosella or rosella), also known as rosa piola in Paraguay, has medicinal use in much of the world; in Paraguay it is used as an antiscorbutic, while in other countries it is used as an antihypertensive, antispasmodic or as an antimicrobial agent, among other uses. Gamma irradiation is used to obtain improved varieties of different plant species; the ANA DELIA and DOGO varieties were obtained by Gamma irradiation as part of INCA's genetic improvement program. The objective of this work was to evaluate the genotoxic and cytotoxic effect of the aqueous extract of calyces of both varieties of currant on bone marrow cells of mice treated with 3 concentrations of each extract, orally, for 15 days. The genotoxic effect was evaluated by applying the Micronucleus test. The cytotoxic effect is verified by the index obtained between the frequency of Polychromatic Erythrocytes (young erythrocytes) and the frequency of Normochromatic Erythrocytes (adult erythrocytes). The results showed that the extracts evaluated, in the concentrations used, do not have a genotoxic or cytotoxic effect on bone marrow cells of mice treated for 15 days with them.

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